![]() Therefore, in the present study, we conducted a retrospective analysis of clinicopathological data of breast cancer patients, to explore the relationships between preoperative serum CEA, CA15-3 levels and clinicopathological parameters, as well as the prognostic value of these two serum biomarkers in breast cancer.įrom January 2002 to December 2004, serum CEA and CA 15–3 in a total of 432 patients who were treated for stage I–III invasive breast cancer at The Affiliated Cancer Hospital of Zhengzhou University were investigated. As a result, the American Society of Clinical Oncology (ASCO) guidelines do not currently recommend the use of serum CA 15–3 and CEA for or screening, diagnosis, staging, or routine surveillance of breast cancer patients after primary therapy. reviewed the role of serum tumor markers in breast cancer and they pointed out conflicting results of its prognostic value. Accordingly, the European Group on Tumor Markers has recommended the CEA and CA15-3 levels be used for assessing prognosis, the early detection of disease progression, and treatment monitoring in breast cancer. Study has shown that preoperative CEA levels combined with CA15-3 levels may provide useful information for diagnosis and treatment of breast cancer. In recent years, the prognostic value of preoperative CEA and CA15-3 levels in breast cancer has gained much attention. In breast cancer, carcinoembryonic antigen (CEA) and cancer antigen 15–3 (CA15-3) are the two most widely used serum tumor markers in the clinical fields for more than 30 years. Along with the traditional pathological factors such as tumor size, tumor grade, lymph node status, molecular markers including hormone receptor status and human epidermal growth factor receptor 2 (HER2) expression, serum tumor markers have an important role in screening, early diagnosis of recurrence, and treatment of many malignancies. ![]() Therefore, it is essential to identify reliable prognostic factors to guide decision making during the treatment of breast cancer in order to improve prognosis. However, once treatment failure occurs the quality of life and the survival rate of patients is significantly affected. Despite the rising incidence of breast cancer, the survival rates have improved in recent years due to the deep research in biology behavior of breast cancer. Breast cancer is the most frequently occurring cancer in women and its incidence has been steadily increasing in China. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |